About Metronidazole: Metronidazole is an antibiotic agent, active against anaerobic bacteria and many species of protozoa. It is used in the treatment of intestinal and systemic amoebiasis, trichomonal infections, bacterial vaginosis and infection anywhere in the body where the causative organism is an anaerobe. Metronidazole is one the most widely used drugs in the world. Though resistance to this antibiotic is rare, rampant use of Metronidazole has resulted in the reporting of some cases of resistant micro-organisms. There are some unpleasant side effects of Metronidazole which have led to the development of other analogous agents that have a similar efficacy but a lower incidence of these side effects such as Tinidazole and Ornidazole. Metronidazole has also been used in regimens for the treatment and eradication of H. Pylori from the stomach.
How Metronidazole Works: Metronidazole is from the nitroimidazole group of anti-biotics, and is the first of this group to be discovered. It is primarily cidal against a variety of anaerobic bacteria and protozoa. Metronidazole has no action against aerobic bacteria. Metronidazole enters the cell through diffusion. The nitro group of Metronidazole is then reduced by redox proteins which are only found in anaerobic micro-organisms, creating a highly reactive nitro radical. This nitro radical exerts the cytotoxicity of Metronidazole by disrupting the pyruvate: ferredoxin oxidoreductase (PFOR) enzyme pathway. This in turn, disrupts the anaerobic metabolism of the organism and eventually leads to dysfunction of multiple enzymes and finally, cell death. The microbes which are resistant to the action of Metronidazole do not have this mechanism that reduces the nitro group in the cell.
How To Take Metronidazole: Buy Metronidazole No Prescription is used in the treatment of intestinal and systemic amoebiasis. The dose for treatment of systemic amoebiasis is higher than that used for local intestinal control of infection. Buy Metronidazole is also used in the management of anaerobic bacterial infections, bacterial vaginosis, trichomonal infection, giardiasis, pseudomembranous enterocolitis, ulcerative stomatitis, as part of anti-H.pylori regimens and as part of drugs used in bowel preparation for surgery. Metronidazole is available as oral tablets in strengths of 400 mg and 800 mg, injectable solutions in concentrations of 250 mg/100 ml and 500 mg/ 100 ml, and as creams and jellies for use in wounds, as a topical agent or for intravaginal use. Metronidazole No Prescription is used for the treatment of trichomonal vaginitis as a dose of 2 g either as single or two divided doses in one day. For the treatment of amoebic dysentery, the recommended dose of Buy Metronidazole Without Prescription is 400 - 800 mg thrice daily after meals usually taken for a duration of 5-7 days. For more serious systemic amoebiasis and liver abscess, intravenous use of Metronidazole is recommended in a dose of 500 mg every 6-8 hrs till oral therapy is resumed after adequate response. Metronidazole is drug of first choice in pseudomembranous colitis and is administered preferably via oral route as 800 mg thrice daily. In the treatment of acute anaerobic bacterial infection, intravenous use of Metronidazole Without Prescription is recommended for serious infections at 7.5 mg/kg every 6 hourly and oral dosage regimens can be used for mild infections.
Precautions And Side Effects Of Metronidazole: Metronidazole No Prescription is not to be used in patients with neurological disease, blood disorders (porphyrias), alcoholics and in the first trimester of pregnancy. It is to be used with caution in patients with hepatic or renal dysfunction and hepatic encephalopathy. Metronidazole Without Prescription is known to cause nausea, vomiting, abdominal pain, diarrhoea, unpleasant taste in the mouth, pain in muscles and joints, dizziness, confusion, visual disturbances. More serious side effects of Buy Metronidazole seen are liver dysfunction, peripheral neuropathy, hallucinations and seizures.